Inheritance of bovine dwarfism and the detection of heterozygotes

Gregory, P; Roubicek, C; Carroll, F; Stratton, P; Hilston, N

Inheritance of bovine dwarfism and the detection of heterozygotes

Authors

P. W. Gregory
C. B. Roubicek
F. D. Carroll
P. O. Stratton
N. W. Hilston

Authors Affiliations

P. W. Gregory was Professor of Animal Husbandry and Animal Husbandman in the Experiment Station Davis; C. B. Roubicek was Western Regional Coordinator, Beef Cattle Research, Bureau of Animal Industry, U. S. Department of Agriculture; F. D. Carroll was Assistant Professor of Animal Husbandry and Assistant Animal Husbandman in the Experiment Station, Davis; P. O. Stratton was Assistant Professor of Animal Production, University of Wyoming; N. W. Hilston was Professor of Animal Production, University of Wyoming.

Publication Information

Hilgardia 22(13):407-450. DOI:10.3733/hilg.v22n13p407. December 1953.

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Abstract

The incidence of dwarfism is Increasing in registered and commercial beef herds throughout the United States. The dwarfism is conditioned by an autosomal recessive gene with complete penetrance. Breeders definitely, though unconsciously, favor the heterozygote in the selection of sires. The dwarf gene in the heterozygous state has such a marked effect upon the frontal bones that heterozygous and homozygous normals can be differentiated, with a high degree of accuracy, from the relationships of the diagnostic points on the head profile. Several different means have been developed for distinguishing the dwarfcarrier and dwarf-free genotypes in mature bulls. Tests in the field under varying conditions indicate that it is feasible to use this method of diagnosis for differentiating between dwarf-carrier and dwarf-free bulls for breeders and commercial cattlemen. The organization of such a program and the problems to be overcome are herein discussed.

This is a report of some of the research work on the California phase of a regional cooperative study in the Western States on Project W-1, “Improvement of Beef Cattle Through the Application of Breeding Methods,” which is partially supported by the Research and Marketing Act of 1946 funds, and is carried on in cooperation with the staff for Beef Cattle Research of the Bureau of Animal Industry, United States Department of Agriculture stotioned at Denver. The New Mexico and Arizona Experiment Station herds provided critical data.

The Western Region comprises the following states and territories: Alaska Agricultural Experiment StationNevada Agricultural Experiment StationArizona Agricultural Experiment StationNew Mexico Agricultural Experiment StationCalifornia Agricultural Experiment StationOregon Agricultural Experiment StationColorado Agricultural Experiment StationUtah Agricultural Experiment StationHawaii Agricultural Experiment StationWashington Agricultural Experiment StationIdaho Agricultural Experiment StationWyoming Agricultural Experiment StationMontana Agricultural Experiment Station

Literature Cited

Apert E. The laws of Naudin-Mendel. Jour. Hered. 1914. 5:492-497.

Baker M. L., et al. Stumpy, a recessive achondroplasia in Shorthorn cattle. Jour. Hered. 1950. 41:243

Baker M. L., et al. Dwarfism in Aberdeen-Angus cattle. Jour. Hered. 1951. 42:141-143.

Carroll F. D., et al. Thyrotropic-hormone deficiency in homozygous dwarf beef cattle. Jour. Anim. Sci. 1951. 10:916-921.

Craft W. A., Orr H. W. Thyroid influence in cattle. Jour. Hered. 1924. 15:255-256.

Crary D. D., Sawin P. B. Morphogenetic studies in the rabbit: VI. Genetic factors influencing the ossification pattern of the limbs. Genetics. 1949. 34:508-523.

Crew F. A. E. The bull-dog calf: A contribution to the study of achondroplasia. Roy. Soc. Med. Proc. 1924. 17:39

Dye J. A., Kinder F. S. A prepotent factor in the determination of skull shape. Amer. Jour. Anat. 1934. 54:333 DOI: 10.1002/aja.1000540207 [CrossRef]

Dye J. A., Maughan G. H. The thyroid gland as a growth-promoting and form-determining factor in the development of the animal body. Amer. Jour. Anat. 1929. 44:331 DOI: 10.1002/aja.1000440302 [CrossRef]

Fisher R. A. Dominance in poultry. Roy. Soc. London, Phil. Trans., Ser. B. 1935. 225:195-226. DOI: 10.1098/rstb.1935.0011 [CrossRef]

Goulden C. H. Methods of statistical analysis. 1952. 2d ed. New York: John Wiley &; Sons, Inc. 467p. DOI: 10.1097/00010694-195301000-00015 [CrossRef]

Green Harry S.N. A dwarf mutation in the rabbit. The constitutional influence on homozygous and heterozygous individuals. Jour. Exp. Med. 1940. 71:839-856. DOI: 10.1084/jem.71.6.839 [CrossRef]

Gregory P. W., et al. A phenotypic expression of homozygous dwarfism in beef cattle. Jour. Anim. Sci. 1951. 10:922-933.

Gregory P. W., et al. Heterozygous expression of the dwarf gene in beef cattle. The Southwestern Veterinarian. 1952. V:345-349.

Gregory P. W., Brown B. B. A profilometer for studying head form of the bovine. Jour. Anim. Sci. 1952. 11(No. 4):704

Johnson L. E., et al. Dwarfism, an hereditary defect in cattle. Jour. Hered. 1950. 41:177

Kidwell J. F., et al. A genetic investigation of allometric growth in Hereford cattle. Genetics. 1952. 37(No. 2):158-174.

Landauer W. Nature of disproportionate dwarfism, with special reference to the fowl. The American Scientist. 1940. 28:171-180.

Liddell H. S. The growth of the head in thyroidectomized sheep. Anat. Rec. 1925. 30:327 DOI: 10.1002/ar.1090300502 [CrossRef]

Lindley C. E. Observations on midgets in beef cattle. Jour. Hered. 1951. 42:273

Lush J. L., Hazel L. H. Inheritance of dwarfism. The American Hereford Journal. 1952. 42(No. 21):32

Seligmann C. G. Congenital cretinism in calves. Trans. Path. Soc. London. 1904. LV:1-20.

Snedecor George W. Statistical methods. 1940. 3d ed. Ames, Iowa: Iowa State College Press. 422p. DOI: 10.1097/00010694-195702000-00023 [CrossRef]

Spielman A. A., et al. General appearance, growth, and reproduction of thyroidectomized bovine. Jour. Dairy Sci. 1945. 28:329 DOI: 10.3168/jds.S0022-0302(45)95182-4 [CrossRef]

Stern Curt. Principles of human genetics. 1949. San Francisco, California: W. H. Freeman and Company. 617p. DOI: 10.1097/00000441-196107000-00030 [CrossRef]

Todd T. W., Wharton R. E. The effect of thyroid deficiency upon skull growth in sheep. Amer. Jour. Anat. 1934. 55:97 DOI: 10.1002/aja.1000550105 [CrossRef]

Ware W. S. Evidence for the expression of the dwarf gene in heterozygous bulls. 1952. University of California. (Unpublished doctoral dissertation.)