Vaccination of swine against tuberculosis with Calmette-Guérin culture, BCG
AuthorsF. M. Hayes
C. M. Haring
Authors AffiliationsF. M. Hayes was Professor of Veterinary Science and Veterinarian in the Experiment Station; C. M. Haring was Professor of Veterinary Science and Veterinarian in the Experiment Station; J. Traum was Professor of Veterinary Science and Veterinarian in the Experiment Station.
Hilgardia 7(6):235-261. DOI:10.3733/hilg.v07n06p235. November 1932.
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Swine being highly susceptible to bovine tuberculosis and, under many systems of swine husbandry, exposed to infectious material from tuberculosis cattle, it was thought advisable to carry out certain experiments at the University of California to test the protective effect of the Calmette-Guérin culture known as BCG, upon hogs under controlled exposures to infection. Results of similar experiments conducted with cattle have already been published by the writers.(5)
Review of Literature
At the time the experiments reported herein were started no publications were known to the writers regarding the immunizing effect of BCG on swine, and contributions appearing since that time are not in agreement.
Ascoli(1),(2) and his collaborators reported an experiment with 12 pigs, 6 of which were vaccinated before the tenth day of age. The other 6 were retained unvaccinated as controls. Of the 6 vaccinated pigs, 3 were given the vaccine by mouth, each receiving a dose of 10 mg on three alternate days.
 Ascoli A. La vaccinazione antitubercolare conbacilli vivi. 1928. 421p. p. Instituto Editoriale Cisalpino, Corso Italia 40, Milano
 Ascoli A. La vaccination antituberculeuse avec les bacilles vivants. 1928. 235p. p. Instituto Editoriale Cisalpino, Corso Italia 40, Milano
 Calmette A. Technic des cultures de BCG. Ann. Inst. Pasteur. 1927. 41:201-252.
 de Blieck L. Remarks. Eleventh International Veterinary Congress. Part 1. 1930. 83 Great Titchfield St., Oxford St. W. 1, London: John Bale Sons and Danielsson, Ltd. 225p.
 Haring C. K., Traum J., Hayes F. M., Henry B. S. Vaccination of calves against tuberculosis with Calmette-Guérin culture, BCG. Hilgardia. 1930. 4:307-394.
 Jerlov S. Cited by Jundell and Magnusson(7) from Svensk Veterinärtidskrift. 1926. 31: 325p.
 Jundell I., Magnus son H. Recherches experimentales relatives a l’action du BCG sur le porc. Ann. Inst. Pasteur. 1931. 47:408-428.
 Sanz M. B. Vaccination des bovides avec le BCG au Chili. Recueil de Méd. Vétér. 1930. 106:136-138.
 Calmette A., Guérin C. Sur le stade lymphatique de l’infection tuberculeuse chez les bovides. Ann. Inst. Pasteur. 1928. 42:175-178.
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