Genetic engineering and cloning may improve milk, livestock production

Murray, J; Anderson, G

Genetic engineering and cloning may improve milk, livestock production

Authors

James D. Murray
Gary B. Anderson

Publication Information

Hilgardia 54(4):57-65. DOI:10.3733/ca.v054n04p57. July 2000.

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Abstract

In the past, procedures such as artificial insemination and embryo transfer have been used in the genetic manipulation of livestock. Advances in gene and quantitative-trait mapping will enhance these traditional animal-breeding approaches to improve farm animals. By genetically engineering livestock, scientists hope to produce animals with altered traits such as disease resistance, wool growth, body growth and milk composition. Laboratories world wide have produced transgenic pigs, sheep, goats and cattle, but currently the efficiency of producing the animals remains low and the procedure is expensive. Within the next few decades, however, genetically engineered dairy cows could become available. Cloning may also be used to duplicate animals with traits that are difficult to capture through traditional breeding practices. By 2025, cloning and breeding of elite animals could be carried out by companies comparable to those that now comprise the artificial insemination industry, which selects and breeds top dairy stock. The acceptance of genetically engineered animals by industry will depend on its economic benefits and whether consumers are prepared to buy the resulting products.

References

Gama LT, Smith C, Gibson JP. Transgene effects, introgression strategies and testing schemes in pigs. Anim Prod. 1992. 54:427-40.

Gordon JW, Scangos GA, Plotkin DJ, et al. Genetic transformation of mouse embryos by microinjection of purified DNA. Proceedings of the National Academy of Sciences USA. 1980. 77:7380-4. https://doi.org/10.1073/pnas.77.12.7380

Gutiérrez-Adán A, Maga EA, Meade HM, et al. Alteration of physical characteristics of milk from bovine kappa-casein transgenic mice. J Dairy Sci. 1996. 79:791-9.

Jimenez-Flores R, Richardson T. Genetic engineering of the caseins to modify the behavior of milk during processing: A review. J Dairy Sci. 1988. 71:2640-54.

Maga EA, Murray JD. Mammary gland expression of transgenes and the potential for altering the properties of milk. Bio/ Technology. 1995. 13:1452-7. PubMed PMID: 9636304

Maga EA, Anderson GB, Cullor JS, et al. Antimicrobial properties of human lysozyme transgenic mouse milk. J Food Protection. 1997. 61:52-6.

Murray JD, Maga EA, Murray JD, Anderson GB, Oberbauer AM, McGloughlin MM. Changing the composition and properties of milk. Transgenic Animals in Agriculture.. 1999. Wallingham, UK: CAB International. 304p.

Murray JD, Anderson GB, Oberbauer AM, McGloughlin MM. Transgenic Animals in Agriculture.. 1999. Wallingham, UK: CAB International. 304.

Nottle MB, Nagashima H, Verma PJ, Murray JD, Anderson GB, Oberbauer AM, McGloughlin MM. Production and analysis of transgenic pigs containing a metallothionein porcine growth hormone gene construct. Transgenic Animals in Agriculture.. 1999. Wallingham, UK: CAB International. 304.

Pinkert CA, Murray JD, Murray JD, Anderson GB, Oberbauer AM, McGloughlin MM. Transgenic farm animals. Transgenic Animals in Agriculture.. 1999. Wallingham, UK: CAB International. 304.

Pursel VG, Wall RJ, Mitchell AD, Murray JD, Anderson GB, Oberbauer AM, McGloughlin MM. Expression of insulin-like growth factor-I in skeletal muscle of transgenic swine. Transgenic Animals in Agriculture.. 1999. Wallingham, UK: CAB International. 304.

Siewerdt F, Eisen EJ, Murray JD, Murray JD, Anderson GB, Oberbauer AM, McGloughlin MM. Direct and correlated responses to short-term selection for 8-week body weight in lines of transgenic (oMt1a-oGH) mice. Transgenic Animals in Agriculture.. 1999. Wallingham, UK: CAB International. 304.

Wall RJ, Hawk HW, Nel N. Making transgenic livestock: Genetic engineering on a large scale. J Cell Biochem. 1992. 49:113-20. https://doi.org/10.1002/jcb.240490203 PubMed PMID: 1400618

Wilmut I, Schnieke AE, McWhir J, et al. Viable offspring derived from fetal and adult mammalian cells. Nature. 1997. 385:810-3. https://doi.org/10.1038/385810a0 PubMed PMID: 9039911

Yom HC, Richardson T. Genetic engineering of milk composition: modification of milk components in lactating transgenic animals. Amer J Clin Nutr. 1993. 58:299S-306S. PubMed PMID: 8328404

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